Prognostic Value of Massiveness Parameters Measured on Baseline FDG PET in Advanced-Stage Hodgkin Lymphoma.

ABSTRACT:

Purpose

The prognostic value of radiomic quantitative features measured on pretreatment ¹⁸F-FDG PET/CT was investigated in patients with advanced-stage Hodgkin lymphoma (HL).

Methods

We conducted a retrospective study of 176 HL patients diagnosed between 2006 and 2017. A dozen of PET/CT-derived features were extracted via Oncometer3D from baseline ¹⁸F-FDG PET/CT images. The receiver operating characteristic (ROC) curves, Kaplan-Meier method, and Cox analyses were used to assess the prognostic factors for Overall Survival (OS) and Progression-Free Survival (PFS) censored at 5 years.

Results

Four different clusters were identified among the 12 PET parameters analyzed: activity, tumor burden, fragmentation-massiveness, and dispersion. On ROC analyse

SUBMITTER: Draye-Carbonnier S 

PROVIDER: S-EPMC12701620 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature