Murine Supraspinatus Tendons Demonstrate Aging-Related Changes in Multiscale Mechanics, Structure, and Gene Expression.

ABSTRACT: Rotator cuff disorders are common in the aging population, often leading to pain, disability, and reduced quality of life. Age-associated changes can occur disproportionately in regions of high mechanical stress, such as the insertion site of the supraspinatus tendon, leading to increased injury rates and tendinopathies. We previously demonstrated site-specific differences in structure, function, and gene expression between the insertion and midsubstance regions of supraspinatus tendons in mature, Day 150 mice. However, a comprehensive study examining the role of aging on site-specific supraspinatus tendon multiscale structure, function, and gene expression is needed. Therefore, our objective was to elucidate the role of aging on supraspinatus tendon multiscale structure, function, and gen

SUBMITTER: DiStefano MS 

PROVIDER: S-EPMC12701629 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature