Contrast-Enhanced Ultrasound (CEUS) Reveals Perfusion of Human Bone in Acute Fracture Healing: A Pilot Study.

ABSTRACT: Bone fractures are common injuries with reported non-union rates of up to 9%. Current treatments for non-union include surgery with complication rates of up to 17% and significant costs. Microbubbles are used clinically in ultrasonography as contrast agents and have been shown to deliver therapeutics to desired locations by noninvasive stimulation of cavitation using extracorporeal ultrasound in preclinical studies. Contrast enhanced ultrasound (CEUS) has been used to determine the cause of established fracture non-unions, though this is not in widespread use clinically. This pilot study aimed to test the hypothesis that peripherally injected microbubbles are detectable in acute fracture sites. Adult patients (18-75 yrs) with acute humeral shaft fractures were recruited to undergo CEUS wit

SUBMITTER: Cadoux-Hudson D 

PROVIDER: S-EPMC12701634 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature