Neutralizing serum IgE upregulates CD88 and CRTH2 expression on basophils in patients with asthma.

ABSTRACT:

Background

The cross-linking of FcεRI by IgE and allergen leads to the degranulation of basophils and mast cells, which can drive allergic reactions. Neutralizing IgE with omalizumab could thus offer clinical benefits to a subset of patients with asthma. However, the mechanisms by which omalizumab interferes with the pathophysiologic functions of blood-circulating granulocytes remain to be fully investigated.

Objective

We sought to investigate how omalizumab affects the frequency and functional phenotypes of blood-circulating granulocytes.

Methods

Longitudinal analyses were conducted on the frequency and surface markers of basophils, eosinophils, and neutrophils in the blood of patients with moderate-to-severe asthma (n = 45; 34 responders and 11 nonresponders) from b

SUBMITTER: Yang A 

PROVIDER: S-EPMC12701675 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature