Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.

ABSTRACT:

Background

The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.

Objective

To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [<80 g/L], and <7 g/dL [<70 g/L]) to guide transfusion in patients with acute MI and anemia.

Design

Prespecified secondary analysis of the MINT (Myocardial Ischemia and Transfusion) trial using target trial emulation methods. (ClinicalTrials.gov: NCT02981407).

Setting

144 clinical sites in 6 countries.

Participants

3492 MINT trial participants with acute MI and a hemoglobin level below 10 g/dL.

Intervention

Four transfusion strategies to maintain patients' hemoglobin c

SUBMITTER: Portela GT 

PROVIDER: S-EPMC12701713 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature