Collagen V Influences Homeostatic Maintenance of Patellar Tendon Failure Properties in Mature Female Mice.

ABSTRACT: The collagenous matrix of tendon provides mechanical integrity, allowing the tissue to withstand large tensile forces. While collagen I-containing fibrils provide the major backbone of the tendon matrix, interactions with other collagen types are critical for matrix formation and maintenance. Of these less abundant collagens, collagen V regulates fibril nucleation and lateral growth. In previous work, mouse models with reduced collagen V production recapitulated the musculoskeletal complications of Classic Ehlers-Danlos Syndrome in tendon development and healing, demonstrating altered structure and inferior mechanical properties. However, the roles of collagen V in homeostasis of mature, healthy tendon remain unknown. Therefore, this study evaluated the role of collagen V in maintaining te

SUBMITTER: Leiphart RJ 

PROVIDER: S-EPMC12701723 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature