International variations in body mass index within the CASiRe global cohort of sickle cell disease patients.

ABSTRACT:

Objectives

Although SCD has traditionally been associated with underweight status, body mass index (BMI) status is shifting globally. As disease-modifying therapies have become available, BMI status has increased. Our aim was to determine the prevalence and risk factors of underweight, overweight, and obese statuses in SCD patients in low-middle and high-income countries.

Methods

The CASiRe research consortium cross-sectionally analyzed the association of BMI status (underweight, normal weight, overweight, and obesity) to age, genotype, treatment status, and associated clinical outcomes of 532 SCD patients from Italy, United States, and Ghana.

Results

Overall, BMI status varied significantly between countries (underweight P < .001, obesity P < .001, over

SUBMITTER: Strunk C 

PROVIDER: S-EPMC12701789 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature