Trolox, r-irisin and resveratrol cocktail to counteract osteoblast metabolism alterations in osteoarthritis and osteoporosis.

ABSTRACT:

Introduction

Osteoarthritis and osteoporosis are age-related musculoskeletal disorders characterized by increased oxidative stress and cellular senescence, which contribute to altered metabolism and disease progression. Although research in this field is constantly evolving, the discovery of new molecular targets and drug combinations to counteract musculoskeletal disorders remains a goal of great interest. This study aimed to evaluate the efficacy of a cocktail of trolox, recombinant irisin (r-irisin) and resveratrol in modulation of osteoblastic metabolism by investigating the expression of NADPH oxidase 4 (NOX4), sirtuin 1 (SIRT1) and pentraxin 3 (PTX3).

Materials and methods

20 male patients undergoing hip arthroplasty were enrolled, including ten patients with coxarthro

SUBMITTER: Bonanni R 

PROVIDER: S-EPMC12701872 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature