Improving reirradiation of recurrent non-small cell lung cancer through non-coplanar beam arrangements.

ABSTRACT:

Background and purpose

Reirradiation for non-small cell lung cancer (NSCLC) is commonly delivered using coplanar techniques. In this study, we investigated whether the selection of favorable non-coplanar beam orientations may limit cumulative doses to critical organs-at-risk (OARs) and thus improve the therapeutic window.

Materials and methods

Fifteen cases of challenging high-dose reirradiation for locoregionally recurrent NSCLC were included in this in-silico study. For each patient, the dose distribution from the previous treatment was first mapped to the new patient anatomy using rigid dose registration, and subsequently converted to equivalent dose in 2 Gy fractions (EQD2). A two-arc non-coplanar reirradiation plan was then generated using an EQD2-based direct aperture

SUBMITTER: Torelli N 

PROVIDER: S-EPMC12701979 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature