Similarities and differences between Alzheimer's disease and schizophrenia: drug target Mendelian randomization and transcriptome analysis.

ABSTRACT: Background: Alzheimer's disease (AD) and schizophrenia (SZ) are two complex neuropsychiatric disorders characterized by significant cognitive impairment. The relationship between them is complex and multifaceted. Understanding these similarities and differences is crucial for identifying common therapeutic targets. Methods: Genetic data on plasma proteome were obtained from Icelandic datasets. Genetic variants associated with circulating inflammatory proteins, rheumatoid arthritis (RA) and AD and SZ, were sourced from large GWAS datasets. Mendelian randomization analyses were performed, and transcriptome analysis were applied to confirm the finding. Results: We observed an association between the genetic loci of the AD and SZ traits (p < 0.05) by Linkage Disequilibrium

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12702048 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature