Histone deacetylase HDA-5 regulates lipid metabolism through H4K5 and H4K8 acetylation in Caenorhabditis elegans.

ABSTRACT: Obesity, a widely recognized pathological factor contributing to the onset of metabolic diseases, has been strongly linked to epigenetic modifications. It is ambiguous how histone modifications, especially histone acetylation, are involved in lipid metabolism. By analyzing existing transcriptome data of Caenorhabditis elegans glp-1(e2141ts) mutants, we found that the expression of six genes encoding histone deacetylases was significantly up-regulated, which was accompanied by a reduction in the histone H4 acetylation at Lysine 5, 8, 12, and 16 in the germline-deficient worms. Of these histone deacetylases, HDA-4, HDA-5, and SIR-2.2 were involved in reduced histone H4 acetylation modifications in glp-1(e2141ts) mutants. Interestingly, lipid accumulation occurred after knockdown of the three

SUBMITTER: Wu QY 

PROVIDER: S-EPMC12702062 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature