Differentiating bacterial from viral respiratory tract infections using CRP, SAA, and blood routine parameters: A retrospective cohort study.

ABSTRACT:

Objective

Respiratory Tract Infections (RTIs) affect millions globally. This retrospective study evaluates routine hematological parameters for distinguishing bacterial from viral RTIs and develops a novel composite biomarker to enhance diagnostic efficiency, optimize treatment decisions, and improve patient outcomes.

Methods

In the present study, 173 RTI cases (55 bacterial, 118 viral) were enrolled and classified by etiological diagnostic methods (Bacterial culture and identification, or PCR). In addition, 80 healthy controls were also enrolled. Data extraction included SAA, CRP, and blood routine parameters. Biomarkers were assessed individually or in combination using SPSS 26.0 (IBM Corp.) to identify optimal diagnostic models.

Results

Predominant pathogens includ

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12702070 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature