Mitral annular disjunction distance is associated with adverse outcomes in children and young adults with connective tissue disorders.

ABSTRACT:

Introduction

Mitral annular disjunction (MAD) is a pathologic fibrous separation of the mitral valve hinge point from the ventricular myocardium. The aims of this study were to describe the range of MAD distance by cardiovascular magnetic resonance (CMR) in children and young adults with connective tissue disorders (CTDs) versus a healthy control sample, and to assess the MAD distance as a predictor of adverse cardiovascular outcomes.

Methods

This was a retrospective, single-center study of healthy subjects and patients with Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, or nonspecific CTD who underwent CMR between January 01, 2000 and January 01, 2020. The MAD distance was measured from the 2-chamber, 4-chamber, and left ventricular outflow tract views in sy

SUBMITTER: Castellanos DA 

PROVIDER: S-EPMC12702100 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature