Leveraging the active conformation of LFA-1 as a potential target for hematological malignancies.

ABSTRACT: Current therapeutic strategies for non-Hodgkin's lymphomas (NHLs) and chronic lymphocytic leukemia (CLL) are limited by systemic toxicity, acquired resistance, and tumor-mediated immune suppression. To address these challenges, we introduce a novel nano-liposomal (NP) delivery system that exploits the overexpressed, open-active conformation of lymphocyte function-associated antigen-1 (LFA-1) on malignant hematopoietic cells. This approach facilitates the selective delivery of Wiskott-Aldrich syndrome (WAS)-specific short interfering RNA (siRNA) to lymphoma and leukemia cells. Compared to conventional therapies, our LFA-1-targeted NP system provides a significant advantage by enhancing cell-specific delivery, thereby minimizing off-target effects and potentially reducing systemic tox

SUBMITTER: Puthenveetil A 

PROVIDER: S-EPMC12702103 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature