Regional four-dimensional cardiac magnetic resonance strain predicts cardiomyopathy progression in Duchenne muscular dystrophy.

ABSTRACT:

Background

Cardiomyopathy (CMP) is the leading cause of death in Duchenne muscular dystrophy (DMD). Characterization of disease trajectory can be challenging, especially in early stages of CMP, where onset and progression may vary. Traditional metrics from cardiovascular magnetic resonance (CMR) imaging, such as left ventricular ejection fraction (LVEF) (left ventricular ejection fraction) and late gadolinium enhancement (LGE) are often insufficient for assessing the pace of disease progression. We hypothesized that strain patterns from a novel four-dimensional (4D) (three-dimensional [3D]+time) CMR regional strain analysis method can be used to predict DMD CMP progression.

Methods

We compiled 190 short-axis cine CMR image stacks for n=66 pediatric DMD patients (age: 13.3 [1

SUBMITTER: Earl CC 

PROVIDER: S-EPMC12702107 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature