GeomeTriD: a Bioconductor package for interactive and integrative visualization of 3D structural model with multi-omics data.

ABSTRACT:

Motivation

The three-dimensional organization of the genome plays a critical role in regulating gene expression by shaping the spatial and temporal interactions between regulatory elements. High-throughput chromosome conformation capture (Hi-C) technologies, along with immunoprecipitation- or chromatin accessibility-based chromatin architecture mapping methods, enable the measurement of chromatin dynamics at both bulk and single-cell levels. However, effectively exploring and comparing chromatin structures remains challenging, particularly when integrating multiple layers of genomic annotation or comparing structural dynamics across conditions. While several tools support interactive 3D genome visualization, few provide a flexible, R-integrated framework that supports custom annota

SUBMITTER: Ou J 

PROVIDER: S-EPMC12702139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature