Magnetic resonance imaging-guided linear accelerator arterial spin labelling reveals dynamics of highly perfused non-enhancing glioblastoma during radiotherapy.

ABSTRACT:

Background and purpose

Targeting tumour vasculature during radiotherapy is a direction of current investigation for radiotherapy strategies in glioblastoma. Arterial spin labelling (ASL), a perfusion imaging technique that uses arterial water as an endogenous tracer, on magnetic resonance imaging (MRI)-guided linear accelerators (MRI-linacs) could guide adaptation to changes in perfusion. However, since ASL is unavailable as a stock sequence on MRI-linac systems, our objective was to implement the first MRI-linac ASL sequence, characterize its performance, and measure tumour perfusion dynamics.

Materials and methods

Forty-seven glioblastoma patients were imaged using 3D pseudo-continuous ASL on a 1.5 T MRI-linac during treatment. ASL labeling efficiency was measured in two h

SUBMITTER: Lawrence LSP 

PROVIDER: S-EPMC12702226 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature