Cerebral amyloid angiopathy in spontaneous intracerebral hemorrhage - radiology and immunohistochemistry in a consecutive surgical series.

ABSTRACT:

Introduction

Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous intracerebral hemorrhage (ICH) in elderly patients and is associated with a high risk of recurrent hemorrhagic events.

Research question

Whether the likelihood of CAA can be estimated using radiological criteria such as the Edinburgh criteria.

Material and methods

We conducted a retrospective analysis of consecutive patients with spontaneous ICH who underwent neurosurgical hematoma evacuation between 01/2023 and 02/2025. Baseline clinical characteristics, radiological findings, and histopathological evaluations were assessed. Patients were classified as CAA-positive or CAA-negative based on immunohistochemical staining for amyloid-β deposition from intraoperative biopsies.

Results

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SUBMITTER: Watzlawick R 

PROVIDER: S-EPMC12702237 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature