Prognostic implications of heart failure rehospitalization in adults with CHD & clinical benefits of medical therapy.

ABSTRACT:

Background

The risk factors for heart failure (HF) rehospitalization, and the effect of guideline directed medical therapy (GDMT) are poorly understood in adults with congenital heart disease (ACHD). We aimed to describe the outcomes of HF hospitalization and to assess the clinical benefits of GDMT for HF.

Methods

We conducted a retrospective cohort study of ACHD hospitalized for HF at Mayo Clinic from 2003 to 2023. Cox proportional hazard models were used to determine the predictors of HF rehospitalization and all-cause mortality, and to assess the association between death and GDMT, as measured by the Heart Failure Collaborative score.

Results

Of the 324 patients, 164 were rehospitalized for HF and 149 died. The 10-year cumulative incidence of rehospitalization was

SUBMITTER: Rosado Rodriguez EP 

PROVIDER: S-EPMC12702253 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature