Reduced gray-white contrast in chronic post-traumatic stress disorder in World Trade Center responders.

ABSTRACT:

Background

Following the collapse of the World Trade Center (WTC), many people experienced severe trauma and 23% of WTC responders developed post-traumatic stress disorder (PTSD). We hypothesized gray-white contrast (GWC) would be different between participants with PTSD when compared to demographically matched trauma-exposed controls with no history of PTSD.

Methods

T1-weighted structural images for 99 WTC responders collected on a 3T Siemen's magnetic resonance imaging were retrieved and segmented to measure global, regional, and voxel-wise GWC. Group-level analyses adjusted for the false discovery rate (FDR=0.05). Area under the receiver-operating curve was reported (AUC). To determine correlates of PTSD, we also measured PTSD symptom severity and several putative neuroim

SUBMITTER: Zhou JW 

PROVIDER: S-EPMC12702304 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature