Elongator is required for pattern recognition receptor and type I interferon signaling in macrophages.

ABSTRACT: Innate immune detection of pathogens by macrophages requires a rapid and large scale mobilization of cellular resources towards an appropriate immune response, mainly involving altered protein expression. Pathogen recognition is mediated by pattern recognition receptor (PRR) sensing of conserved microbial patterns, a prototypical example being recognition of lipopolysaccharide by Toll-like receptor 4. This leads to induction of pro-inflammatory cytokines, chemokines and type I interferons (IFNs) which together mobilize appropriate anti-pathogen responses. Type I IFNs signal to transcription of IFN-stimulated genes which encode numerous anti-viral proteins. Many studies have contributed to a detailed understanding of transcriptional regulation of mRNA during such responses, however much les

SUBMITTER: Murphy J 

PROVIDER: S-EPMC12702316 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature