PIEZO mechanosensitivity in chondrocytes is differentially modulated by L-type and T-type voltage-sensitive ion channels.

ABSTRACT:

Objective

One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca²⁺) channels (VGCCs) have been shown to contribute to Ca²⁺ influx into chondrocytes in response to mechanical loads.

Design

To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca²⁺ response to mechanical loading or Yoda1 (a PIEZO1 agonist) after various classes of VGCCs were chemically inhibited. We also studied the effec

SUBMITTER: Savadipour A 

PROVIDER: S-EPMC12702332 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature