Bifunctional 3D-printed PEEK scaffolds incorporating hydrogel-encapsulated magnesium-quinone nanosheets for antibacterial activity and mandibular bone regeneration.

ABSTRACT: Infectious mandibular bone defects present significant clinical challenges due to the complex pathological microenvironment, risk of persistent bacterial colonization, and insufficient bone regeneration. Poly (ether ketone) (PEEK) is considered a promising alternative to metallic implants owing to its bone-mimetic mechanical properties; however, its intrinsic hydrophobicity and bioinertness hinder osseointegration and functional recovery. Here, a bifunctional 3D-printed porous PEEK scaffold coated with an alginate hydrogel encapsulating magnesium-aloe emodin (MgAe) nanosheets (AP@MgAe) was developed to achieve simultaneous antibacterial and osteogenic functions. MgAe nanosheets were synthesized via metal-quinone coordination-driven self-assembly, enabling the co-delivery of bioactive Mg

SUBMITTER: Su Q 

PROVIDER: S-EPMC12702351 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature