A tripartite therapeutic agent reprograms the myocardial infarction microenvironment.

ABSTRACT: Myocardial infarction (MI) remains a global health challenge despite advances in reperfusion therapies, as subsequent oxidative stress, inflammatory cascades, and electrical conduction abnormalities impede functional recovery. This study presents a tripartite therapeutic strategy addressing these pathological mechanisms through a clinically translatable multifunctional myocardial repair agent (MMRA). The system combines polypyrrole's and sinomenine's (Sino) anti-inflammatory/antioxidant effects, formulated within a conductive thermoresponsive Poloxamer 407 (P407) hydrogel platform. Injectable P407 hydrogel facilitates targeted delivery and sustained release of therapeutic components within the infarct zone. In vivo evaluations revealed MMRA's capacity to simultaneously: 1) Scavenge reactiv

SUBMITTER: Zhu K 

PROVIDER: S-EPMC12702353 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature