Interplay between biological & social vulnerability and poor tuberculosis treatment outcome in Brazil: a nationwide study using multivariate modelling with excess risk.

ABSTRACT:

Background

Focusing on socially vulnerable sub-populations at increased risk of tuberculosis is warranted to decrease the disease burden. In this study, we evaluated whether homelessness, living with HIV, incarceration, pregnancy, immigration, drug use, and healthcare work are inter-related risk factors for unfavorable anti-tuberculosis treatment (ATT) outcomes in Brazil through analysis of national disease registry database (SINAN).

Methods

We conducted a retrospective cohort study of tuberculosis cases ≥18 years-old reported to SINAN between 2015 and 2023. Clinical and epidemiologic variables were compared between groups (non-vulnerability, homeless, people deprived of their liberty, pregnant women, people with HIV, people who use drugs, immigrants and healthcare worker).

SUBMITTER: Barreto-Duarte B 

PROVIDER: S-EPMC12702379 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature