Metastasis-directed thermal ablation in patients with metastatic breast cancer and visceral oligoprogression or oligopersistence: a cohort study.

ABSTRACT:

Background

Patients with visceral oligoprogressive and oligopersistent metastatic breast cancer (mBC) may benefit from metastasis-directed thermal ablation (TA) to all sites of metastasis, while maintaining the same systemic treatment, in order to delay the time to treatment failure (TTF). This study aims to assess the outcomes provided by this multimodal strategy.

Methods

We conducted a single-center, cohort study including consecutive patients with visceral oligoprogressive and oligopersistent mBC as per ESTRO/EORTC criteria, who underwent TA to all sites. Oligoprogression was defined as progressive disease in ≤5 metastatic sites with at least one other metastatic site maintaining the disease control; oligopersistence as ≤5 persistent lesions after systemic therapy. The ma

SUBMITTER: Bianco N 

PROVIDER: S-EPMC12702380 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature