Vasopressin, steroids, and epinephrine in out-of-hospital cardiac arrest - a protocol for a randomized controlled trial (OHCA REVIVES trial).

ABSTRACT:

Objective

Several clinical trials have shown promising results for the vasopressin-steroid-epinephrine (VSE) triple therapy in patients experiencing in-hospital cardiac arrest (IHCA); however, this treatment strategy has not yet been studied in the prehospital setting. The OHCA REVIVES (A Randomized Clinical Trial of Patient Outcomes Following Out-of-Hospital Cardiac Arrest Receiving Epinephrine Versus In-together Vasopressin, Epinephrine, and Steroid) trial aims to evaluate the effectiveness of the VSE combined therapy in improving clinical outcomes in patients with out‑of‑hospital cardiac arrest (OHCA).

Methods

The OHCA REVIVES trial is an investigator-initiated, multicenter, superiority cluster randomized controlled trial. Adult non-traumatic patients with OHCA treated by

SUBMITTER: Ko YC 

PROVIDER: S-EPMC12702410 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature