Metabolomic signatures reveal mechanisms of rumen-protected glutathione in mitigating oxidative stress and regulating inflammatory networks in transition dairy cows.

ABSTRACT: Glutathione (GSH) is widely found in animal cells and is essential for combating oxidative stress and inflammation. However, whether dietary GSH alleviates these processes in dairy cows remains unknown. The purpose of this research was to assess how supplementation with rumen-protected glutathione (RPG) influences oxidative stress, inflammation, and serum metabolites in transition dairy cows. One hundred multiparous Holstein cows (2.63 ± 0.76 of parity, 2.83 ± 0.18 of body condition score, 9388.53 ± 1242.48 kg of previous 305-day milk yield, 655.08 ± 58.05 kg of body weight) were initially assigned to five treatment groups (n = 20 per group) from a cohort of 3215 cows. After excluding cows with health disorders, 50 healthy cows were randomly divided into five dietary treatment group

SUBMITTER: Song Y 

PROVIDER: S-EPMC12702415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature