SABRE-SHEATH Hyperpolarization of [1,5-¹³C₂]Z-OMPD for Noninvasive pH Sensing.

ABSTRACT: Hyperpolarized (HP) ¹³C-labeled probes are emerging as promising agents to noninvasively image pH in vivo. HP [1,5-¹³C₂]Z-OMPD (Z-4-methyl-2-oxopent-3-enedioic acid) in particular has recently been used to simultaneously report on kidney perfusion, filtration, and pH homeostasis, in addition to the ability to detect local tumor acidification. In previous studies, dissolution dynamic nuclear polarization was used to hyperpolarize Z-OMPD. Here, we pioneered the hyperpolarization of [1,5-¹³C₂]Z-OMPD via SABRE-SHEATH (signal amplification by reversible exchange in shield enabling alignment transfer to heteronuclei), which is relatively simple and fast and promises to be highly scalable. With SABRE-SHEATH, we achieve enhancement values of ∼

SUBMITTER: Abdulmojeed MB 

PROVIDER: S-EPMC12702418 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature