Identification of Genetic Risk Factors Associated With Herbal and Dietary Supplement-Induced Acute Liver Failure Using Whole Exome Sequencing Analysis.

ABSTRACT:

Background and aims

Herbal and dietary supplements (HDS) have been associated with liver injury and severe liver disease, including acute liver failure (ALF), collectively referred to as HDS-induced ALF (HDS-ALF). With the global increase in HDS usage, reports of HDS-ALF cases have also risen.

Methods

Genetic analysis was conducted using whole exome sequencing data from 23 HDS-ALF cases, with population controls sourced from the 1000 Genomes Project. Single-nucleotide polymorphisms (SNPs) with chi-square test P values less than 5 × 10^-8 and stable allele frequencies across different ethnicities and healthy controls were considered statistically significant. Variants were also analyzed based on supplement type (herbal vs dietary) and sex (female vs male).

SUBMITTER: Liao TJ 

PROVIDER: S-EPMC12702431 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature