The bidirectional relationship between knee osteoarthritis and frailty in China: A longitudinal study.

ABSTRACT:

Background

Knee osteoarthritis is a common disease that causes disability and loss of independence in middle-aged and older adults, and may interact with frailty through shared pathways. Understanding their bidirectional relationship is clinically meaningful for early intervention. This study aimed to investigate the associations between knee osteoarthritis and frailty among middle-aged and older adults in China.

Methods

The data for this study came from three waves (baseline 2011, follow-up 2013 and 2015) of the China Health and Retirement Longitudinal Study (CHARLS). A total of 3560 participants were included. Frailty was assessed with the Frailty Index. Knee osteoarthritis was defined as physician-diagnosed arthritis with self-reported knee pain. Longitudinal bidirectiona

SUBMITTER: Tian Z 

PROVIDER: S-EPMC12702434 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature