Patient-Reported Outcome Scores Are Comparable in Multiregional Versus Uniregional Eosinophilic Esophagitis.

ABSTRACT:

Background and aims

Eosinophilic esophagitis (EoE) clinical trials often require multiregional esophageal inflammation. To determine if patient-reported outcomes (PROs) worsen with multiregional eosinophil inflammation (≥15 eosinophils/high power field), we compared outcomes scores when multiple (proximal/mid/distal) esophageal regions, versus one, were inflamed.

Methods

The Consortium of Eosinophilic Gastrointestinal Disorders Researchers database was searched for peak eosinophil counts (PECs), eosinophilic esophagitis histology scoring system scores, and PRO scores (eosinophilic esophagitis activity index; Pediatric Eosinophilic Esophagitis Symptom Score; EoE quality of life; Pediatric Quality of Life Eosinophilic Esophagitis modulev3.0) in submissions from one or more reg

SUBMITTER: Collins MH 

PROVIDER: S-EPMC12702438 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature