<i>Salvia miltiorrhiza</i> water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.

ABSTRACT:

Objective

To investigate the potential of Salvia miltiorrhiza water extract (SMWE) as a modulator of the cGAS-STING signaling pathway, which is implicated in the pathogenesis of immune and inflammatory disorders, and to elucidate its underlying mechanism of action through in vitro and in vivo experiments.

Methods

The cGAS-STING signaling pathway was activated in bone marrow-derived macrophages (BMDMs), Tohoku hospital pediatrics-1 (THP-1) cells, and peripheral blood mononuclear cells (PBMCs). The effect of SMWE on the expression of phosphorylated interferon regulatory factor 3 (IRF3) and phosphorylated STING after aberrant activation of the cGAS-STING pathway was detected by immunoblotting. Subsequently, real-time quantitative PCR was performed to detect

SUBMITTER: Li C 

PROVIDER: S-EPMC12702439 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature