Potential prognostic biomarkers in restenosis of peripheral arteries identified through comprehensive ceRNA network analysis.

ABSTRACT: Peripheral artery disease (PAD) is one of the leading causes of amputation and mortality worldwide, with restenosis being a common complication following vascular interventional therapy that significantly impacts patient prognosis. This study aims to identify potential biomarkers with clinical and prognostic significance for restenosis of peripheral arteries (RPA). To achieve this, RNA expression levels in stenotic vascular tissues from healthy controls and patients with RPA were integrated and analyzed, identifying a growing number of differentially expressed RNAs for the construction of a competitive endogenous RNA (ceRNA) network for prognostic analysis. The analysis revealed that the RNA expression patterns of samples from patients with RPA were significantly different compared with th

SUBMITTER: Miao Y 

PROVIDER: S-EPMC12702502 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature