Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury.

ABSTRACT:

Background

Severe burn injuries can cause long-term cognitive impairments, potentially driven by lipid-mediated neuroinflammation in the central nervous system (CNS). The disruption of lipid homeostasis may contribute to neuroinflammatory responses, exacerbating neuronal damage. This study investigates whether acipimox, an anti-lipolytic agent, modulates lipid accumulation and neuroinflammation in the prefrontal cortex following severe burns.

Methods

Sprague Dawley rats were randomized into four groups: sham vehicle, sham acipimox, burn vehicle, and burn acipimox. A scald injury covering 40-60% of total body surface area was induced, and rats were treated with acipimox (50 mg/kg/day, intraperitoneally) or vehicle for seven days. Lipidomic analysis assessed alterations in lip

SUBMITTER: O'Leary S 

PROVIDER: S-EPMC12702713 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature