HMOX1 mRNA combined with early imaging parameters for predicting the prognosis of hypertensive cerebral hemorrhage patients undergoing conservative treatment.

ABSTRACT:

Objective

To address the limitations of current clinical tools in predicting the prognosis of hypertensive cerebral hemorrhage (HICH) patients undergoing conservative treatment, this study aimed to evaluate the predictive value of combining HMOX1 mRNA levels with early imaging parameters.

Methods

This retrospective diagnostic accuracy study involved 208 HICH patients (mean age 50 ± 9.5 years, 149 men) treated from December 2022 to December 2024. Patients were divided into good prognosis (mRS score ≤ 2, n = 112) and poor prognosis (mRS score > 2, n = 96) groups based on 90-day mRS scores. The index tests were HMOX1 mRNA levels and early imaging parameters (hemorrhage location, hematoma volume, and shape), with the reference standard being the 90-day mRS score. S

SUBMITTER: Dong J 

PROVIDER: S-EPMC12702738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature