Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes.

ABSTRACT: Preeclampsia (PE) is a pregnancy-specific disorder marked by systemic immune imbalance and placental dysfunction, yet the link between peripheral molecular changes and tissue-level immune alterations remains incompletely understood. In this study, we integrated bulk transcriptomic analysis of peripheral blood from pregnant women at high risk for PE with single-cell RNA sequencing (scRNA-seq) of placental tissues to identify key immune-associated genes and explore their functional relevance. Transcriptome-wide differential expression, immune cell deconvolution, co-expression network analysis, and machine learning-based feature selection led to the identification of five candidate genes. Among them, TCL1A, CLEC2B, and LGALS9 exhibited robust expression in both datasets a

SUBMITTER: Zheng S 

PROVIDER: S-EPMC12702750 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature