Inflammation in Diabetic Kidney Disease Is Linked to Gut Dysbiosis and Metabolite Imbalance.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is characterized by a sustained pro-inflammatory response of the immune system, which leads to renal failure progression and related complications. Emerging evidence suggests that gut microbiota dysregulation may be a pathogenic mediator in DKD, while mechanisms remain unclear. This study aimed to identify differences in the gut microbiota of the DKD group and healthy controls (HC).

Methods

Gut microbiota composition was determined using shotgun metagenomic sequencing on fecal samples; serum cytokines were measured via ELISA, immune phenotypes were detected using flow cytometry.

Results

Significant differences in gut microbiota diversity and richness were observed between patients with DKD and HC, with higher abundances of Ente

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12702812 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature