Acetyl-11-keto-beta-boswellic acid ameliorates monosodium iodoacetate-induced osteoarthritis in rats: implications of HMGB1/TLR4/NF-κB and Nrf2/HO-1.

ABSTRACT:

Introduction

Osteoarthritis (OA) is a prevalent joint disorder marked by chronic inflammation and degradation of cartilage. The shielding effect of 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been confirmed in many inflammatory disorders. However, the full underlying mechanistic perspective of AKBA against OA remains unexplored. Thus, the objective of this work is to identify additional unexamined modulatory signals of AKBA against monosodium iodoacetate (MIA)-induced OA and the early prevention of irreversible cartilage damage.

Methods

Male Wistar rats were allotted into three groups (n = 9): sham, MIA-OA, and MIA + AKBA250. Three mg of MIA was injected intra-articularly into the right knee joints of rats to induce OA on day 0. All treatments were given orally, daily, st

SUBMITTER: Abo-Zalam HB 

PROVIDER: S-EPMC12702862 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature