Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) exhibits marked heterogeneity and variable benefit from immune checkpoint inhibitors (ICIs). Post-translational modifications (PTMs) regulate immune signaling and tumor behavior, yet PTM-informed biomarkers for ccRCC remain underexplored.

Methods

We intersected immune-related genes, PTM-related genes, and differentially expressed genes in TCGA-KIRC to derive candidates and built a prognostic model across TCGA and E-MTAB-1980 using multiple algorithms, selecting a random survival forest-based post-translational modification-related signature (PTMRS) with the best performance. Prognostic value and independence were evaluated by time-dependent ROC, Kaplan-Meier, and multivariate Cox analyses. Tumor immune context was profiled b

SUBMITTER: Li Z 

PROVIDER: S-EPMC12702869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature