Impact of aging on the central and enteric nervous system in a Parkinson's disease mouse model.

ABSTRACT: The etiopathogenesis of Parkinson's Disease (PD) remain poorly understood, particularly the roles of aging and the gut-brain axis. This study investigated the impact of aging on the development of PD hallmarks, including neurodegeneration and inflammation, in both the central (CNS) and enteric (ENS) nervous system of mice following exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Young (2-4 months) and adult (7-12 months) mice were treated with either saline or MPTP (four intraperitoneal injections of 8 mg/kg at 2-hour intervals). Postmortem inflammatory and neuronal endpoints were compared in both the nigrostriatal pathway and the myenteric plexus. While age did not alter the MPTP-induced reduction in TH-positive cells in the striatum and substantia nigra pars compacta (SN

SUBMITTER: Pradeloux S 

PROVIDER: S-EPMC12702875 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature