Alterations in gut microbiota and plasma metabolites: a multi-omics study of mild cognitive impairment in Parkinson's disease.

ABSTRACT:

Introduction

Emerging evidence suggests that gut microbiota and plasma metabolites may be associated with the onset and progression of Parkinson's disease (PD). The interplay between gut microbiota and plasma metabolites in influencing the progression of cognitive impairment in PD is yet to be fully understood and requires further exploration. Our objective was to investigate the roles of gut microbiota and plasma metabolites in PD cognitive impairment.

Methods

We initially recruited 100 individuals with PD and 50 healthy controls (HCs). After excluding participants based on education level and cognitive screening criteria, the final cohort comprised 38 PD patients and 40 HCs. We examined fecal and plasma specimens from these participants. Cognitive function was assessed via

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12702881 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature