Vasomotor responses are similar between outbred UM-HET3 and inbred C57BL/6J male and female mouse mesenteric resistance arteries.

ABSTRACT:

Objective

Genetically diverse UM-HET3 (HET3) mice have emerged as a more robust model of human large artery dysfunction than the commonly used inbred C57BL/6J (C57) mice. However, HET3 resistance artery function has not been examined. The purpose of this study was to examine HET3 versus C57 mesenteric resistance artery agonist-induced vasomotor responses to phenylephrine (PE) and acetylcholine (ACh), PE-induced myoendothelial feedback (endothelium-dependent feedback dilation to PE-induced vasoconstriction) and its underlying mechanisms, and eNOS (an enzyme involved in endothelium-dependent dilation) expression.

Hypothesis

Vasomotor responses, mechanisms, and eNOS protein expression would be similar between HET3 and C57 mesenteric resistance arteries of both sexes.

Methods

SUBMITTER: Looft-Wilson RC 

PROVIDER: S-EPMC12702883 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature