Shifting mortality patterns of primary liver cancer in the United States: a 20-year analysis of disparities.

ABSTRACT:

Background

Primary liver cancer is a leading cause of cancer-related mortality worldwide. Despite its significant disease burden, long-term trends in primary liver cancer mortality across diverse demographic and geographic populations in the United States (U. S.) remain insufficiently characterized.

Methods

We analyzed national mortality data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2020. Deaths were identified using International Classification of Diseases, Tenth Revision (ICD-10) codes C22.0-C22.9, encompassing hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and other specified or unspecified liver cancers. Age-adjusted mortality rates (AAMRs) were calcu

SUBMITTER: Zhao H 

PROVIDER: S-EPMC12702890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature