Association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults.

ABSTRACT:

Background

Age-related eye diseases are the main causes of progressive and irreversible vision loss in aging populations worldwide. Carotenoids, as a group of common natural antioxidants, can suppress free radicals produced by complex physiological reactions, thereby protecting the eyes from the effects of oxidative stress, cell apoptosis, and mitochondrial dysfunction. The present study aims to explore the association between serum carotenoid concentrations and risk of major age-related eye diseases among middle-aged and older adults in the United States.

Methods

This study involved 1,478 participants aged ≥50 years from the 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was used to estimate the odds ratio

SUBMITTER: Che S 

PROVIDER: S-EPMC12702905 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature