Changes in voxel-wise gray matter asymmetry over time.

ABSTRACT: Hemispheric brain asymmetries emerge in early life but continue to change over time. However, there is no consensus on whether asymmetries become weaker or stronger with age or which brain regions are most affected. Here, we set out to further explore age-related changes in brain asymmetry, with a particular focus on voxel-wise gray matter asymmetry. For this purpose, we selected a sample of 2,322 participants (1,150 women/1,172 men), aged between 47 and 80 years (mean 62.3 years), from the UK Biobank. Each participant was scanned twice; with an interval between baseline and follow-up scans ranging between 1 and 7 years (mean 2.4 years). Significant changes in asymmetry were observed, particularly in the temporal and occipital lobe, as well as the cerebellum. Overall, decreases in asymmetr

SUBMITTER: Kurth F 

PROVIDER: S-EPMC12702909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature