An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure.

ABSTRACT:

Aims

To investigate alterations of cognitive function, roles of cyclin-dependent kinase 5 (CDK5) and changes of brain structure in Alzheimer's disease (AD) with obstructive sleep apnea (OSA).

Methods

Total 94 AD with OSA (AD-OSA) patients were divided into 49 cases of AD with mild OSA (AD-OSA-M) and 45 cases of AD with moderate and severe OSA (AD-OSA-MS). Demographic characteristics, cognitive function, the levels of AD neuropathological proteins, CDK5 and synaptic proteins in cerebrospinal fluid (CSF), and brain volume by magnetic resonance imaging were compared between the two groups. The correlations among OSA and the above variables were analyzed.

Results

Compared with AD-OSA-M group, AD-OSA-MS group had a higher body mass index, lower scores of AVLT N7 and SCWT-C

SUBMITTER: Luo D 

PROVIDER: S-EPMC12702912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature