Correlation between oral microbial characteristics and overall bone density of Postmenopausal women based on macrogenomic analysis.

ABSTRACT:

Background

Postmenopausal osteoporosis (PMO), a prevalent bone disease triggered by estrogen deficiency - induced bone mass reduction and deterioration of bone tissue microarchitecture, escalates the risk of fragility fractures. Recent research has highlighted the pivotal role of oral and gut microbiota in PMO development, giving rise to the "oral - gut - bone axis" concept.

Methods

A total of 21 postmenopausal women, aged 50 - 60, were recruited for the study. Based on bone mineral density (BMD) measurements from dual - energy X - ray absorptiometry (DXA), participants were divided into osteopenia, osteoporosis, and healthy groups. Saliva and dental plaque samples were collected for metagenomic sequencing to analyze microbial diversity and community composition, with differ

SUBMITTER: Liu M 

PROVIDER: S-EPMC12702920 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature