Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

This study aimed to investigate the efficacy and safety of esketamine in reducing postpartum pain and depression in patients undergoing cesarean delivery (CD).

Methods

Web of Science, Embase, PubMed, and Cochrane Library were searched from the inception of each database up to September 2025 to select relevant studies. Randomized controlled trials (RCTs) that assessed the efficacy of esketamine for pain control in patients undergoing CD were selected. The outcomes included scores of postpartum pain, the incidence of depression after surgery, scores on the Edinburgh Postnatal Depression Scale, and the incidence of adverse events before and after surgery. The stability of the results and potential sources of heterogeneity were investigated by subgroup and sensitivity

SUBMITTER: Jiang T 

PROVIDER: S-EPMC12702921 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature