The relationships between Life's Crucial 9, Life's Essential 8, and sarcopenia in older adults: multicenter case-control study.

ABSTRACT:

Background

Sarcopenia, the age-related loss of muscle mass and strength, is aggravated by cardiometabolic and psychosocial burden. Life's Essential 8 (LE8) and its mental-health extension Life's Crucial 9 (LC9) quantify cardio-psycho-metabolic risk, yet their relationship with sarcopenia remains untested.

Methods

Multicenter case-control study of 1,316 consecutive inpatients (≥65 years) enrolled 2019-2025 at two tertiary hospitals in Nanyang, China (Nanyang Central Hospital, n = 740; Nanyang Second People's Hospital, n = 576). Sarcopenia was adjudicated by AWGS-2019. LE8 and LC9 were derived from admission nicotine, diet, sleep, physical activity, BMI, blood pressure, glucose, non-HDL-C, and PHQ-9. Multivariable logistic regression, ROC, and re-classification a

SUBMITTER: Li H 

PROVIDER: S-EPMC12702946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature